Novel psychoactive substances (NPS) often produce negative toxicology results, leaving clinicians without clear answers during acute events. This brief discussion introduces the SENTINEL-NPS framework, a mnemonic-based tool that helps teams assess ambiguous presentations. Learn how to identify patterns in physiological signs, differentiate conflicting toxidromes, and make informed decisions about escalating care when clinical findings and screening results do not align.

• Describe novel psychoactive substances classes most common in correctional settings
• Apply the SENTINEL-NPS mnemonic framework to identify physiological markers of toxicity from synthetic cannabinoids, nitazenes, and synthetic stimulants
• Explain when to escalate suspected NPS exposure within the interprofessional team

Level: Intermediate